In a large pot or Dutch oven, brown the beef chuck over medium-high heat. Drain any excess grease.
Add minced garlic, diced jalapenos, diced red onions, diced tomatoes, and diced yellow or white onion to the pot. Cook until softened, about 2-3 minutes.
Stir in black pepper, brown sugar, chili powder, Italian seasoning blend, kosher salt, masa harina, smoked paprika, and red pepper flakes.
Add the kidney beans and enough water to cover the ingredients.
Bring the chili to a boil, then reduce heat and simmer for 2-3 hours or until the beef is tender.